Featured Articles in Feb 2018

A Note from the New Editor in Chief

 

Author list: Julie Ann Sosa

 

Abstract:

It is an honor and a privilege to assume the role of Editor in Chief of World Journal of Surgery, following in the (large) footsteps of my mentor, colleague, and friend, Dr. John Hunter. There have been only four other EICs—Drs. Marshall Orloff, James Hardy, Samuel Wells, and Ronald Tompkins, all international leaders in surgery and surgical science. Together, they have helped to mold WJS into the journal uniquely positioned to serve as the premiere international forum for original research, guidelines, and perspectives around major clinical problems in the fields of clinical and experimental surgery, surgical education, and socioeconomic aspects of surgical care.

 

URL: http://rdcu.be/DZ5l


An Evolving Understanding of the Clinical Implications of NIFTP

 

Author list: Linwah Yip, Sally E. Carty

 

Abstract:

Papillary thyroid cancer (PTC) is the most common type of thyroid cancer diagnosed and overall is associated with an excellent prognosis (>95% 5-year survival). However, PTC is comprised of a heterogeneous group of histologic subtypes with varying biologic behavior, and accurate histologic characterization can improve disease prognostication [1].

 

URL: http://rdcu.be/DZ5H


Ten-Year Follow-Up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter

 

Author list: Marcin Barczynski, Aleksander Konturek, Alicja Hubalewska-Dydejczyk, Filip Golkowski, Wojcieh Nowak

 

Abstract:

Background

The aim of this study was to validate in a 10-year follow-up the initial outcomes of various thyroid resection methods for multinodular non-toxic goiter (MNG) reported in World J Surg 2010;34:1203–13.

 

Methods

Six hundred consenting patients with MNG were randomized to three groups of 200 patients each: total thyroidectomy (TT), Dunhill operation (DO), bilateral subtotal thyroidectomy (BST). Obligatory follow-up period of 60 months was extended up to 120 months for all the consenting patients. The primary outcome measure was the prevalence of recurrent goiter and need for revision thyroid surgery. The secondary outcome measure was the cumulative postoperative and post-revision morbidity rate.

 

Results

The primary outcomes were twice as inferior at 10 years when compared to 5-year results for DO and BST, but not for TT. Recurrent goiter was found at 10 years in 1 (0.6%) TT versus 15 (8.6%) DO versus 39 (22.4%) BST (p < 0.001), and revision thyroidectomy was necessary in 1 (0.6%) TT versus 5 (2.8%) DO versus 14 (8.0%) BST patients (p < 0.001). Any permanent morbidity at 10 years was present in 5 (2.8%) TT patients following initial surgery versus 7 (4.0%) DO and 10 (5.7%) BST patients following initial and revision thyroidectomy (nonsignificant differences). At 10 years, 23 (11.5%) TT versus 25 (12.5%) DO versus 26 (13.0%) BST patients were lost to follow-up.

 

Conclusion

Total thyroidectomy can be considered the preferred surgical approach for patients with MNG, as it abolishes the risk of goiter recurrence and need for future revision thyroidectomy when compared to more limited thyroid resections, whereas the prevalence of permanent morbidity is not increased at experienced hands.

 

URL: http://rdcu.be/DZ6f


Lithium-Associated Hypercalcemia: Pathophysiology, Prevalence, Management

 

Author list: Adrian D. Meehan, Ruzan Udumyan, Mathias Kardell, Mikael Landen, Johannes Jarhult, Goran Wallin

 

Abstract:

Background

Lithium-associated hypercalcemia (LAH) is an ill-defined endocrinopathy. The aim of the present study was to determine the prevalence of hypercalcemia in a cohort of bipolar patients (BP) with and without concomitant lithium treatment and to study surgical outcomes for lithium-associated hyperparathyroidism.

 

Methods

Retrospective data, including laboratory results, surgical outcomes and medications, were collected from 313 BP treated with lithium from two psychiatric outpatient units in central Sweden. In addition, data were collected from 148 BP without lithium and a randomly selected control population of 102 individuals. Logistic regression was used to compare odds of hypercalcemia in these respective populations.

 

Results

The prevalence of lithium-associated hypercalcemia was 26%. Mild hypercalcemia was detected in 87 out of 563 study participants. The odds of hypercalcemia were significantly higher in BP with lithium treatment compared with BP unexposed to lithium (adjusted OR 13.45; 95% CI 3.09, 58.55; p = 0.001). No significant difference was detected between BP without lithium and control population (adjusted OR 2.40; 95% CI 0.38, 15.41; p = 0.355). Seven BP with lithium underwent surgery where an average of two parathyroid glands was removed. Parathyroid hyperplasia was present in four patients (57%) at the initial operation. One patient had persistent disease after the initial operation, and six patients had recurrent disease at follow-up time which was on average 10 years.

 

Conclusions

The high prevalence of LAH justifies the regular monitoring of calcium homeostasis, particularly in high-risk groups. If surgery is necessary, bilateral neck exploration should be considered in patients on chronic lithium treatment. Prospective studies are needed.

 

URL: http://rdcu.be/DZ7v


Modification of the Surgical Strategy for the Dissection of the Recurrent Laryngeal Nerve Using Continuous Intraoperative Nerve Monitoring

 

Author list: Stan Sidhu

 

Abstract:

The manuscript by Arteaga and colleagues from the Endocrine Surgery Unit of the University Hospitals of Geneva highlights several pertinent issues regarding the preservation of the function of the recurrent laryngeal nerve during thyroid surgery [1]. Their Unit has routinely used intermittent intraoperative neuromonitoring (I-IONM) since 2008 and has prospectively documented their experience with continuous intraoperative neuromonitoring (C-IONM) in selected difficult cases since 2012 including redo surgery, thyroid cancer surgery, large retrosternal goitres and Graves’ disease. It behoves all surgeons undertaking the use of new technology to prospectively document their own outcomes in order to validate the technology in their hands [2]. Having achieved a low recurrent laryngeal nerve palsy (RLNP) rate utilising I-IONM of 2.8% at the end of thyroidectomy and 1.4% confirmed at laryngoscopy on Day 1 post-surgery, 0.8% at 3 months and 0.06% permanent injury at 6 months, the authors are striving to further improve their temporary nerve injury rate which can affect patient function for several months. While there are those that would consider temporary RLNP of minimal consequence, for those in voice-reliant professions, being unable to function normally for up to 6 months is a significant impediment.

 

URL: http://rdcu.be/DZ7H


A Multi-institutional Comparison of Adrenal Venous Sampling in Patients with Primary Aldosteronism: Caution Advised if Successful Bilateral Adrenal Vein Sampling is Not Achieved

 

Author list: Tracy S. Wang, Greg Kline, Tina W. Yen, Ziyan Yin, Ying Liu, William Rilling, Benny So, James W. Findling, Douglas B. Evans, Janice L. Pasieka

 

Abstract:

Background

In patients with primary aldosteronism (PA), adrenal venous sampling (AVS) is recommended to differentiate between unilateral (UNI) or bilateral (BIL) adrenal disease. A recent study suggested that lateralization could be predicted, based on the ratio of aldosterone/cortisol levels (A/C) between the left adrenal vein (LAV) and inferior vena cava (IVC), with a 100% positive predictive value (PPV). This study aimed to validate those findings utilizing a larger, multi-institutional cohort.

 

Methods

A retrospective review was performed of patients with PA who underwent AVS from 2 tertiary-care institutions. Laterality was predicted by an A/C ratio of >3:1 between the dominant and non-dominant adrenal. AVS results were compared to LAV/IVC ratios utilizing the published criteria (Lt ≥ 5.5; Rt ≤ 0.5).

 

Results

Of 222 patients, 124 (57%) had UNI and 98 (43%) had BIL disease based on AVS. AVS and LAV/IVC findings were concordant for laterality in 141 (64%) patients (69 UNI, 72 BIL). Using only the LAV/IVC ratio, 54 (24%) patients with UNI disease on AVS who underwent successful surgery would have been assumed to have BAH unless AVS was repeated, and 24 (11%) patients with BIL disease on AVS may have been incorrectly offered surgery (PPV 70%). Based on median LAV/IVC ratios (left 5.26; right 0.31; BIL 2.84), no LAV/IVC ratio accurately predicted laterality.

 

Conclusions

This multi-institutional study of patients with both UNI and BIL PA failed to validate the previously reported PPV of LAV/IVC ratio for lateralization. Caution should be used in interpreting incomplete AVS data to differentiate between UNI versus BIL disease and strong consideration given to repeat AVS prior to adrenalectomy.

 

URL: http://rdcu.be/DZ71


Minimally Invasive Adrenalectomy for Adrenocortical Carcinoma: Five-Year Trends and Predictors of Conversion

 

Author list: Natalie A. Calcatera, Chi Hsiung-Wang, Nicholas R. Suss, David J. Winchester, Tricia A. Moo-Young, Richard A. Prinz

 

Abstract:

Background

Adrenocortical carcinoma (ACC) is rare but often fatal. Surgery offers the only chance of cure. As minimally invasive (MI) procedures for cancer become common, their role for ACC is still debated. We reviewed usage of MI approaches for ACC over time and risk factors for conversion using a large national database.

 

Methods

ACC patients with localized disease were identified in the National Cancer Data Base from 2010 to 2014. A retrospective review examined trends in the surgical approach over time. Patient demographics, surgical approach, and tumor characteristics between MI, open, and converted procedures were compared.

 

Results

588 patients underwent adrenalectomy for ACC, of which 200 were minimally invasive. From 2010 to 2014, MI operations increased from 26 to 44% with robotic procedures increasing from 5 to 16%. The use of MI operations compared to open was not different based on facility type (p = 0.40) or location (p = 0.63). MI tumors were more likely to be confined to the adrenal (p < 0.001) but final margin status was not different (p = 0.56). Conversion was performed in 38/200 (19%). Average tumor size was 10.2 cm in the converted group compared to 8.6 cm in the MI group (p = 0.09). There was no difference in extent of disease (p = 0.33), margin status (p = 0.12), or lymphovascular invasion (p = 0.59) between MI and converted procedures. Tumor size > 5 cm was the only significant predictor of conversion (p = 0.04). No patients with pathologic stage I disease required conversion (0/19).

 

Conclusions

The frequency of MI approaches for ACC is increasing. In the final year of the study, 44% of adrenalectomies were MI. Size > 5 cm was the only significant predictor of conversion.

 

URL: http://rdcu.be/DZ8d


A Nationwide Population-Based Study on the Survival of Patients with Pancreatic Neuroendocrine Tumors in The Netherlands

 

Author list: C. G. Genc, H. J. Klumpen, M. G. H. van Oijen, C. H. J. van Eijck, E. J. M. Nieveen van Dijkum

 

Abstract:

Background

Large population-based studies give insight into the prognosis and treatment outcomes of patients with pancreatic neuroendocrine tumors (pNETs). Therefore, we provide an overview of the treatment and related survival of pNET in the Netherlands.

 

Methods

Patients diagnosed with pNET between 2008 and 2013 from the Netherlands Cancer Registry were included. Patient, tumors and treatment characteristics were reported. Survival analyses with log-rank testing were performed to compare survival.

 

Results

In total, 611 patients were included. Median follow-up was 25.7 months, and all-cause mortality was 42%. Higher tumor grade and TNM stage were significantly associated with worse survival in both the overall and metastasized population. The effect of distant metastases on survival was more significant in lower tumor stages (T1–3 p < 0.05, T4 p = 0.074). Resection of the primary tumor was performed in 255 (42%) patients. Patients who underwent surgery had the highest 5-year survival (86%) compared to PRRT (33%), chemotherapy (21%), targeted therapy and somatostatin analogs (24%) (all p < 0.001). Patients with T1M0 tumors (n = 115) showed favorable survival after surgical resection (N = 95) compared to no therapy (N = 20, p = 0.008). Resection also improved survival significantly in patients with metastases compared to other treatments (all p > 0.05). Without surgery, PRRT showed the best survival curves in patients with distant metastases. Grade 3 tumors and surgical resection were independently associated with survival (HR 7.23 and 0.12, respectively).

 

Conclusions

Surgical resection shows favorable outcome for all pNET tumors, including indolent tumors and tumors with distant metastases. Prospective trials should be initiated to confirm these results.

 

URL: http://rdcu.be/DZ8O


 

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